Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study. - Abstract - Europe PMC
Adaptive designs for dual-agent phase I dose-escalation studies | Nature Reviews Clinical Oncology
Dose-Finding Schemes in Clinical Trials
Illustration of the chronic dose-limiting toxicity (DLT) concept. (*)... | Download Scientific Diagram
Cancers | Free Full-Text | Ibrutinib Associated with Rituximab-Platinum Salt-Based Immunochemotherapy in B-Cell Lymphomas: Results of a Phase 1b-II Study of the LYSA Group
Would the Recommended Dose Have Been Different Using Novel Dose-Finding Designs? Comparing Dose-Finding Designs in Published Trials | JCO Precision Oncology
Exposure driven dose escalation design with overdose control: Concept and first real life experience in an oncology phase I trial - ScienceDirect
A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia | PLOS ONE
1. In a typical Phase I clinical trial of a new drug, | Chegg.com
Entropy | Free Full-Text | Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding
Cancers | Free Full-Text | Maximum Tolerated Dose and Anti-Tumor Activity of Intraperitoneal Cantrixil (TRX-E-002-1) in Patients with Persistent or Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer: Phase I
Determining drug dose in the era of targeted therapies: playing it (un)safe? | Blood Cancer Journal
Flexibility of the BLRM in Dose-Escalation Trials
Study design. PK, pharmacokinetics; DLT, dose- limiting toxicity | Download Scientific Diagram
Dose Limiting Toxicities (DLT) DOSE LIMITING TOXICITIES (DLT) Example: Dose escalation will proceed within each cohort according
Phase I trials - memoinOncology
A Bayesian Logistic Model with Covariate to Identify Optimal Dose for Heterogeneous Population in Phase I Oncology Trial Xin Wei, Mike Branson Celgene. - ppt download
Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol. - Abstract - Europe PMC
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect
Early phase clinical trials to identify optimal dosing and safety - Cook - 2015 - Molecular Oncology - Wiley Online Library
Study protocol: phase 1 dose escalating study of Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) with oxaliplatin in peritoneal metastasis
Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol | BMJ Open
Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial - eClinicalMedicine
Cureus | Phase 1 First-in-Human Dose Escalation and Dose Expansion Study of KLS-1 (64Zinc Aspartate) in Patients With Cancer and Neurodegenerative Diseases | Article
Diagram of the inter-subject or inter-cohorts' escalation. DLT:... | Download Scientific Diagram
Study design for dose-escalation cohorts and DLT rate (as calculated by... | Download Scientific Diagram
